Comparative chemical composition and pesticidal evaluation of Acorus calamus accessions collected from different geographical locations

The objectives of the present study were to investigate phytochemical composition essential oils (EO) from rhizomes Acorus calamus collected Jorhat, Assam; Munsyari and Pantnagar, Uttarakhand, India. EOs studied for different pesticidal activities viz; nematicidal, insecticidal, herbicidal activity. To synergistic effect on activity, four combinations prepared. Phenylpropanoids with β-asarone as main compound identified in all collections varying percentages. Its contribution was found be 85.8% followed by 74.3% Pantnagar 62.6% Assam collections. All exhibited dose-dependent vitro nematicidal activity against Meloidogyne incognita terms immobility inhibition egg hatching. observed maximum EO combination three (1:1:1) whereas minimum In insecticidal Lipaphis erysimi Selepa celtis, mortality assessed sprout seed germination inhibition, coleoptile growth shoot root Raphanus raphanistrum. Maximum % shoot, combinations. predict possible mode action structure-activity relationship between major compounds biological activities, silico molecular docking ADME/Tox studies performed. results revealed proteins insects, nematodes, weeds support experiments. may helpful development herbal-based pesticides after proper clinical trials.